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Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13362-6.

Heteromultimeric CLC chloride channels with novel properties.

Author information

1
Center for Molecular Neurobiology, Hamburg University, Germany.

Abstract

The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.

PMID:
8917596
PMCID:
PMC24098
DOI:
10.1073/pnas.93.23.13362
[Indexed for MEDLINE]
Free PMC Article

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