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Ann Trop Med Parasitol. 1996 Oct;90(5):467-74.

Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.

Author information

1
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.

Abstract

Seventy-seven primaquine analogues were evaluated for their effectiveness in reducing the parasitaemias in female albino mice (aged 4-6 weeks) which had been infected with a Brazilian strain of Trypanosoma cruzi 15 days earlier. Of the analogues tested, 23 were more effective than the reference drug, nifurtimox, and one was > 14-fold as effective as the standard and almost four times as active as primaquine itself. Certain members of the series tested warrant further evaluation.

PMID:
8915122
DOI:
10.1080/00034983.1996.11813071
[Indexed for MEDLINE]

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