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FEBS Lett. 1996 Nov 4;396(2-3):213-7.

Genetic diversity of flagellins of Pseudomonas aeruginosa.

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Klinische Forschergruppe, Medizinische Hochschule Hannover, Max-Planck-Institut für experimentelle Endokrinologie, Germany.


Physical genome analysis of the virulence-associated fliC locus in 20 Pseudomonas aeruginosa strains by mapping and sequencing revealed groups of heterologous a-type (1164 bp; 1185 bp) and highly conserved b-type (1467 bp) flagellin genes. Whereas only two synonymous nucleotide substitutions were detected in eight b-type fliC sequences, the 12 a-type sequences exhibited 57 nucleotide substitutions, of which 39 occurred within a variable central region. Although a-type and b-type flagellins differ by 35% in their primary structure, they share strong homology in their predicted features, implying that the polymorphic proteins fold into similar structures during polymerization of the flagella.

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