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Neuropeptides. 1996 Aug;30(4):309-12.

Decreased neurotrophin-3 expression in skeletal muscles of streptozotocin-induced diabetic rats.

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Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan.


The expression of neurotrophin-3 (NT-3) in skeletal muscles was measured in rats with streptozotocin (STZ)-induced diabetes using Northern blot analysis. At 6 weeks after STZ induction of diabetes, the NT-3 mRNA level in the quadriceps and gastrocnemius muscles was decreased by 45 and 77%, respectively, compared with that in age-matched controls. Since NT-3 is considered to be essential for the maintenance of spinal proprioceptive afferent neurons, decreased NT-3 expression in target tissues would impair the integrity of afferent neurons and might be an earlier marker in the sensory neuronal damage observed in diabetes mellitus.

[Indexed for MEDLINE]

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