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Biophys J. 1996 Nov;71(5):2501-8.

Faster voltage-dependent activation of Na+ channels in growth cones versus somata of neuroblastoma N1E-115 cells.

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1
Neuroscience Program, University of Connecticut Health Center, Farmington 06030, USA.

Abstract

Kinetics of voltage-gated ionic channels fundamentally reflect the response of the channels to local electric fields. In this report cell-attached patch-clamp studies reveal that the voltage-dependent activation rate of sodium channels residing in the growth cone membrane differs from that of soma sodium channels in differentiating N1E-115 neuroblastoma cells. Because other electrophysiological properties of these channels do not differ, this finding may be a reflection of the difference in intramembrane electric field in these two regions of the cell. This represents a new mechanism for channels to attain a range of activities both within and between cells.

PMID:
8913589
PMCID:
PMC1233738
DOI:
10.1016/S0006-3495(96)79443-2
[Indexed for MEDLINE]
Free PMC Article
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