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Biochem Biophys Res Commun. 1996 Nov 1;228(1):88-93.

Seleno compounds and glutathione peroxidase catalyzed decomposition of S-nitrosothiols.

Author information

1
Department of Chemistry, University of Miami, Coral Gables, Florida 33124, USA.

Abstract

Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric oxide. It was also found that glutathione peroxidase itself can catalyze the decomposition of S-nitrosoglutathione without the presence of any thiol or H2O2.

PMID:
8912640
DOI:
10.1006/bbrc.1996.1620
[Indexed for MEDLINE]

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