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Arthritis Rheum. 1996 Nov;39(11):1869-74.

Abnormal carnitine distribution in the muscles of patients with idiopathic inflammatory myopathy.

Author information

1
Hospital Doce de Octubre, Madrid, Spain.

Abstract

OBJECTIVE:

To analyze the levels of free carnitine and carnitine esters in the muscles of patients with inflammatory myopathies.

METHODS:

Six men and 7 women with inflammatory myopathy and 25 age-matched healthy controls were studied. Free carnitine and carnitine esters in muscle homogenates were measured by a radiochemical procedure. Muscle histochemical staining and measurement of respiratory chain enzyme activity were also performed.

RESULTS:

Eleven patients had muscle carnitine insufficiency. Five of them had subsarcolemmal oxidative accumulations, 5 had lipid droplets, and 4 had defects of the respiratory chain enzyme complexes.

CONCLUSION:

Abnormal distribution of muscle carnitine is present in patients with inflammatory myopathies and could impair muscle function. Coexistent mitochondrial dysfunction may contribute to carnitine insufficiency.

PMID:
8912509
[Indexed for MEDLINE]

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