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J Mol Med (Berl). 1996 Oct;74(10):563-71.

Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

Author information

1
Institute of Cancer Research, Chester Beatty Laboratories, London, UK.

Abstract

The Rho family of low molecular weight GTP-binding proteins control important aspects of cell shape, adhesion, movement and growth. The DBL-homology (DH) protein family of upstream regulators of Rho GTPases has recently been identified, and deregulated expression of these proteins can have dramatic cellular consequences. This review examines the possible role of DH proteins and Rho GTPases in oncogenesis, metastasis and development.

PMID:
8912177
DOI:
10.1007/s001090050060
[Indexed for MEDLINE]

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