Format

Send to

Choose Destination
Urology. 1996 Nov;48(5):817-21.

A deficit of chondroitin sulfate proteoglycans on the bladder uroepithelium in interstitial cystitis.

Author information

1
Department of Urology, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, USA.

Abstract

OBJECTIVES:

To investigate the abundance of chondroitin sulfate proteoglycans at the bladder lumenal and subepithelial surfaces in bladder biopsies derived from patients with interstitial cystitis (IC) and controls.

METHODS:

Tissue sections derived from biopsies from 31 IC patients and 24 pathologically normal control sections were labeled for proteoglycans using the 2B6 anti-"stub" antibody and detected by immunohistochemistry.

RESULTS:

On the lumenal surface, 5 of 31 (19%) IC sections were positive for proteoglycans versus 14 of 24 (58%) control sections (P = 0.00011). At the basal surface, 5 of 19 IC patients were positive versus 7 of 12 controls (P = 0.032).

CONCLUSIONS:

A deficit of bladder lumenal and basal proteoglycans is associated with IC. The deficit in basal layer proteoglycans suggests an altered urothelial differentiation program. The lumenal deficit suggests that the charge-dependent exclusion of ions from the bladder surface is compromised in IC.

PMID:
8911536
DOI:
10.1016/S0090-4295(96)00322-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center