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Med Hypotheses. 1996 Oct;47(4):321-5.

A unifying theory of atherogenesis.

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Department of Pathology, Louisiana State University School of Medicine at New Orleans, LA 70112, USA.


The author proposes that all major risk factors, including elevated serum low-density lipoprotein, cause atherosclerosis by increasing viscosity, creating larger areas of decreased blood flow, thereby perpetuating the interaction of atherogenic elements with the endothelium. Low-density lipoprotein causes increased viscosity by fostering erythrocyte aggregation. High-density lipoprotein protects against atherosclerosis by antagonizing erythrocyte aggregation, thereby decreasing viscosity. Implications of this theory are discussed.

[Indexed for MEDLINE]

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