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J Pediatr Endocrinol Metab. 1996 Jul-Aug;9(4):455-61.

Acute hyperglycaemia impairs cognitive function in children with IDDM.

Author information

1
Department of Diabetes/Endocrinology, Princess Margaret Hospital for Children, Perth, Western Australia.

Abstract

OBJECTIVE:

The effects of acute hyperglycaemia on cognitive function in children remain controversial. This study was designed to investigate the suggestion that acute hyperglycaemia impairs cognition in IDDM children.

DESIGN:

To examine this question we studied 12 randomly selected children with IDDM (6 boys, 6 girls, mean age 12.4 years). Cognitive performance was assessed on two occasions at least six months apart (7.4 +/- 1.4 mths, range: 6.3-11.1 mths) under randomised conditions of hyperglycaemia (20-30 mmol/l) on one occasion and euglycaemia (5-10 mmol/l) on the other. Target glucose levels were achieved using a modified clamp technique with subjects and psychologist blinded to the glycaemic level. Cognitive tests chosen to assess performance skills were subtests from the Wechsler Intelligence Scale for Children-3rd Edition (WISC-111).

RESULTS:

No significant learning effect was present. However, there was a reduction in performance IQ at hyperglycaemia compared with euglycaemia (106 +/- 4.3 vs 112 +/- 4.5 IQ points respectively, p < 0.05). Under hyperglycaemic conditions the mean decrease in percentile score for performance IQ was 9.5%. Of the 12 children tested, 8 had a decrease in IQ when hyperglycaemic, which was independent of duration of diabetes and long term metabolic control assessed by HbA1c.

CONCLUSION:

Acute hyperglycaemia results in impairment of complex cognitive function in children with IDDM. This may have important implications for school performance.

PMID:
8910814
[Indexed for MEDLINE]

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