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Nature. 1996 Nov 14;384(6605):134-41.

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.

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Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.


Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.

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