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J Lipid Mediat Cell Signal. 1996 Sep;14(1-3):197-202.

Phosphatidylcholine hydrolysis and protein kinase C activation for intracellular signaling network.

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Department of Biochemistry, Kobe University School of Medicine, Japan.


Agonist-stimulated inositol phospholipid hydrolysis by phospholipase C was once thought to be the sole mechanism to produce diacylgylcerol that transduce extracellular signals into intracellular events through activation of protein kinase C. It is becoming clear that agonist-induced hydrolysis, of the other membrane phospholipids, particularly phosphatidylcholine, by phospholipase A2 and phospholipase D also takes part in cellular responses such as cell proliferation and differentiation. Possibly, the members of the protein kinase C family may be activated differently by various combinations of phospholipid degradation products, and play each distinct role in signal transduction for the control of various cellular functions.

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