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Arch Ophthalmol. 1996 Nov;114(11):1339-43.

Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma.

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1
Department of Paediatric Oncology, St. Bartholomew's Hospital, London, England.

Abstract

OBJECTIVE:

To determine the visual anatomical results and survival after combined chemotherapy and whole eye radiotherapy for patients with bilateral Reese-Ellsworth group V retinoblastoma.

SETTING:

A national referral center for retinoblastoma.

PATIENTS:

Fourteen patients with bilateral Reese-Ellsworth group V retinoblastoma seen between March 1, 1989, and April 30, 1995, were treated.

INTERVENTIONS:

Patients were treated with chemotherapy (using carboplatin, etoposide, and vincristine) and whole eye radiotherapy (40-44 Gy in 20-22 equivalent fractions). A medical record review was performed to determine outcomes.

MAIN OUTCOME MEASURES:

Survival, eye preservation rate, and visual acuity.

RESULTS:

Two patients died, 1 from a primitive neuroectodermal tumor and the other from the meningeal spread of retinoblastoma. Four eyes were enucleated primarily because of severe disease at presentation. Of the remaining 20 eyes, 6 required enucleation. The disease recurred in 4 of those patients, and neovascular glaucoma developed in 2 patients. Of the 12 surviving children, 5 have a visual acuity better than l/60 in at least 1 eye.

CONCLUSION:

Although most of the treated group V eyes could be salvaged with chemotherapy plus radiotherapy, the resultant visual acuity was often poor.

PMID:
8906024
[Indexed for MEDLINE]
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