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Int J Cancer. 1996 Nov 4;68(3):291-4.

Genomic instability in colorectal cancers in Turkey.

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Department of Molecular Oncology, Research Institute for Genetic Engineering and Biotechnology, TUBITAK, Marmara Research Center, Gebze, Turkey.


Microsatellite instability in a subset of colorectal cancers from North America, Europe and Japan has been reported. We examined 88 colorectal cancers from Turkish patients. Five different microsatellite loci (1 mono- and 4 dinucleotide repeat regions) were tested. Eight tumors displayed replication errors (RERs) with at least 2 different markers. Right-sided tumors showed significantly higher frequency of microsatellite instability compared with left-sided tumors. The frequency of RER phenotype was slightly higher in tumors occurring in younger (<50 years old) than in older patients (13% vs. 8%), and there was no association between sex and genomic instability. The frequency of genomic instability in our study group was 9%, whereas the reported frequencies in tumors from other countries varied between 12% and 16%.

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