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Curr Opin Immunol. 1996 Oct;8(5):681-7.

Antigen processing and presentation in transplantation.

Author information

1
Massachusetts General Hospital, Department of Surgery and Transplantation, Boston 02114, USA. Auchincloss@helix.mgh.harvard.edu

Abstract

For many years the direct stimulation of T cells in response to donor MHC antigens expressed on donor antigen-presenting cells has been the focus of transplantation immunology. Indirect recognition in response to peptides of donor antigens presented by self MHC molecules on recipient antigen-presenting cells has not generally been considered an important feature of graft rejection. Recent evidence suggests that indirect responses may be more important than previously considered and the new emphasis on indirect pathways in allograft rejection has raised new issues, many of which are unresolved.

PMID:
8902394
DOI:
10.1016/s0952-7915(96)80086-0
[Indexed for MEDLINE]

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