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Curr Opin Immunol. 1996 Oct;8(5):658-63.

The new vaccines: building viruses that elicit antitumor immunity.

Author information

1
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. restifo@helix.nih.gov

Abstract

Whereas cancer cells are poor immunogens, some viruses are capable of eliciting powerful and lifelong immunity. Recombinant viruses and plasmid DNA encoding tumor-associated antigens can elicit powerful and specific immune responses that can be enhanced by the use of cytokines and costimulatory molecules. These immune responses have destroyed growing tumor cells in experimental animal models. For the first time, immunotherapeutic strategies that employ recombinant viruses are being tested in clinical trials with cancer patients.

PMID:
8902391
PMCID:
PMC1950785
DOI:
10.1016/s0952-7915(96)80082-3
[Indexed for MEDLINE]
Free PMC Article

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