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Curr Opin Immunol. 1996 Oct;8(5):628-36.

Human tumor antigens recognized by T cells.

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Surgery Branch, National Institutes of Health, National Cancer Institute, Bethesda, MD 20892-1502, USA.


The ability of tumor-reactive T cells to mediate in vivo tumor regression has been demonstrated in murine tumor models and by the clinical responses to adoptive immunotherapy with tumor-infiltrating lymphocytes isolated from human melanomas. Investigations carried out in the past several years have resulted in the isolation of a number of the genes encoding antigens recognized by melanoma-reactive T cells. The ability of these products to serve as tumor regression antigens has now begun to be evaluated in clinical vaccine trials.

[Indexed for MEDLINE]

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