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Biomedicine. 1977 Apr;27(3):99-102.

EEG and extracelluar K+ in rat brain during pentylenetetrazol seizures and during respiratory arrest.


The relationship between changes in EEG and the extracellular potassium concentration (K+e) in brain cortex was studied in rats during petylenetetrazol seizures and during respiratory arrest. During seizures an increase of K+e occurred subsequent to the electrical discharges, while during postictal depression of EEG normal levels of K+e were measured. During respiratory arrest K+e rose considerably one minute after flattering of EEG. These findings are against a concept of K+e determining the changes of the EEG pattern. It is hypothetized that during seizures the increased K+e may play an important role in the coupling of neuronal activity to cerebral blood flow and metabolism.

[Indexed for MEDLINE]

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