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Trends Microbiol. 1996 Oct;4(10):394-400.

Long-term humoral immunity against viruses: revisiting the issue of plasma cell longevity.

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1
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30307, USA.

Abstract

Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are not fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.

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PMID:
8899965
DOI:
10.1016/0966-842X(96)10059-7
[Indexed for MEDLINE]

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