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Cytokine Growth Factor Rev. 1996 Aug;7(2):133-41.

The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors.

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Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.


The epidermal growth factor receptor (EGFR) is detected on many non-haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-alpha, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.

[Indexed for MEDLINE]

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