Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Med Today. 1996 Oct;2(10):432-8.

Neurotrophin receptors, tumor progression and tumor maturation.

Author information

1
Department of Medicine, Lund University, University Hospital MAS, Malmö, Sweden. sven.pahlman@medforsk.mas.lu.se

Abstract

The nerve growth factor receptor TrkA was initially isolated as a transforming oncogene, trk, in which most of the extracellular receptor part is replaced by the coding sequence for a tropomyosin-encoding gene. The impact that the identification of the first neurotrophin receptor has made on the entire field of developmental neurobiology cannot be overstated. Following a brief introduction to the biology of neurotrophins and their receptors, this review will focus on oncogenic Trk in human malignant disorders, discuss putative tumorigenic involvement of Trk family members in the childhood malignancy neuroblastoma, and point out potential neurotrophin-based treatment modalities for this and other neuroendocrine tumors.

PMID:
8897438
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center