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Nature. 1996 Nov 7;384(6604 Suppl):11-3.

The combinatorial chemistry of nature.

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1
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

Powerful new technologies such as high-throughput screening and combinatorial chemistry are revolutionizing drug discovery. But natural products still offer unmatched structural variety, especially as new environmental niches are explored, and their usefulness can be further extended by engineering the proteins that produce them and by using them to probe biological pathways.

PMID:
8895593
DOI:
10.1038/384011a0
[Indexed for MEDLINE]
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