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Science. 1996 Nov 15;274(5290):1123-33.

The molecular biology of axon guidance.

Author information

1
Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

Abstract

Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.

PMID:
8895455
[Indexed for MEDLINE]

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