Format

Send to

Choose Destination
See comment in PubMed Commons below
Xenobiotica. 1996 Sep;26(9):887-95.

Interspecies scaling: predicting clearance of drugs in humans. Three different approaches.

Author information

1
Division of Pharmaceutical Evaluation I. Food & Drug Administration, Rockville, MD 20852, USA.

Abstract

1. The interspecies scaling approach to predict clearance in humans from animal data was tested for a wide variety of drugs. 2. Three different methods were utilized to generate plots to scale-up the clearance values: (i) method I, clearance versus body weight (simple allometric equation); (ii) method II, product of clearance and maximum life-span potential; (iii) method III, product of clearance and brain weight versus body weight. 3. The circumstances under which the three methods can be applied to predict clearance in humans were evaluated. 4. If the exponent lies between 0.55 to 0.7 then method I predicts clearance reasonably well. 5. If the exponent lies between 0.71 to 1.0 clearance can be predicted reasonably well by method II. 6. If the exponent is > 1.0 clearance can be predicted using method III.

PMID:
8893036
DOI:
10.3109/00498259609052491
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center