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Dermatology. 1996;193(2):124-6.

Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy.

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1
F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Abstract

BACKGROUND:

9-cis-Retinoic acid (9-cis-RA) is as active as 13-cis-retinoic acid (13-cis-RA) in inhibiting the proliferation of cultured human sebocytes and in reducing the size of sebaceous glands of hamsters.

OBJECTIVE:

Evaluate the anti-acne effect of 9-cis-RA compared to that of 13-cis-RA in a pilot study.

METHODS:

Four young male patients with acne were treated in an open study consecutively with 9-cis-RA and 13-cis-RA given at similar doses.

RESULTS:

No beneficial effects were observed with 9-cis-RA in any of the patients whereas all responded favorably to 13-cis-RA.

CONCLUSION:

For the two retinoids tested, the anti-acne effect correlates with the sebosuppressive effect in humans.

PMID:
8884148
DOI:
10.1159/000246226
[Indexed for MEDLINE]

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