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Brain Res. 1996 Aug 19;730(1-2):238-42.

Nitric oxide synthase is concentrated at the skeletal muscle endplate.

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  • 1Department of Neurology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Department of Veterans Affairs Medical Center, OH 44106, USA.

Abstract

NO performs a wide array of cell signaling functions. Neuronal NO synthase (nNOS) immunoreactivity and nicotinamide adenine dinucleotide phosphate diaphorase (NDP) activity, a marker of nNOS, were concentrated at adult rat neuromuscular junctions and persisted in denervated muscle indicating the localization of the enzyme to the postsynaptic surface. The concentration of nNOS at the muscle endplate suggests NO could serve as a messenger pre- and postsynapticly.

PMID:
8883910
[PubMed - indexed for MEDLINE]

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