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Trends Biochem Sci. 1996 Mar;21(3):102-6.

The role of MCM/P1 proteins in the licensing of DNA replication.

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ICRF Clare Hall Laboratories, South Mimms, UK.


The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.

[Indexed for MEDLINE]

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