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Trends Biochem Sci. 1996 Mar;21(3):96-102.

Proteasomes: destruction as a programme.

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Institut für Biochemie, Universität Stuttgart, Germany.


Proteasomes are large multi-subunit protease complexes that selectively degrade intracellular proteins. Most of the proteins removed by these proteases are tagged for destruction by ubiquitination. Proteasomes have a role to play in controlling cellular processes, such as metabolism and the cell cycle, through signal-mediated proteolysis of key enzymes and regulatory proteins. They also operate in the stress response, by removing abnormal proteins, and in the immune response, by generating antigenic peptides.

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