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Trends Biochem Sci. 1996 Mar;21(3):89-96.

Chemical kinetic theory: understanding cell-cycle regulation.

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Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.


Progress of a cell through its reproductive cycle of DNA synthesis and division is governed by a complex network of biochemical reactions controlling the activities of both M-phase- and S-phase-promoting factors. Standard chemical kinetic theory provides a disciplined method for expressing the molecular biologists' diagrams and intuition in precise mathematical form, so that qualitative and quantitative implications of our 'working models' can be derived and compared with experiment.

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