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J Comp Physiol B. 1996;165(8):640-6.

Mediation of serotonin-induced hyperventilation via 5-HT3-receptor in European eel Anguilla anguilla.

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Faculté des Sciences et Techniques, Laboratoire de Physiologie Animale, Brest, France.


The effects of serotonin (5-hydroxytryptamine) on ventilation were investigated by continuous measurements of intrabuccal pressure in unrestrained eel. Intravenous administration of 5-hydroxytryptamine (30 caused a large increase in ventilatory frequency (+ 100%) and amplitude (+ 140%). The 5-hydroxytryptamine-induced hyperventilation was blocked by the 5-HT3-receptor antagonists metoclopramide (1.0 or MDL72222 (1.0, and was insensitive to the 5-HT1/2-receptor antagonist methysergide (3.0 and to the 5-HT4-receptor antagonist DAU 6285 CL (3.0 The hyperventilatory response to 5-hydroxytryptamine could be mimicked by the 5-HT3 receptor agonist 1-phenylbiguanide (300 These results strongly implicate the 5-HT3-receptor as the mediator of the 5-hydroxytryptamine-induced hyperventilation in eel.

[Indexed for MEDLINE]

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