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Hematol Oncol Clin North Am. 1996 Oct;10(5):1011-21.

Pathogenesis of AIDS--related Kaposi's sarcoma. Evidence of a viral etiology.

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Department of Medicine, University of California, Los Angeles, School of Medicine, USA.


Kaposi's sarcoma is the most common malignancy in patients with HIV infection. New studies point to the involvement of a new human Kaposi's sarcoma herpes virus (KSHV) as a transforming agent. After transformation, cytokine perturbations facilitate growth and in some cases clonal growth occurs. This results in a malignancy with devastating clinical consequences. A clear understanding of the mechanism of transformation by KSHV will lead to better therapies.

[Indexed for MEDLINE]

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