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Endocrinol Metab Clin North Am. 1996 Sep;25(3):591-614.

The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action.

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Department of Pediatrics, University of Pennsylvania, Children's Hospital of Philadelphia, USA.


Over the past few years, there has been an explosion of data in the scientific literature regarding the various components of the IGF axis. IGFBPs and related molecules are now believed to be critical elements in numerous cellular processes and key factors in several disease states related to abnormal tissue and somatic growth. Recently, the BP-Prs were included in this complex system, and their importance is being unraveled. The upcoming years will undoubtedly bring even more information on the molecular biology of these key cellular regulators. These discoveries are likely to lead to better understanding of growth and cellular regulation and to development of novel therapeutic approaches to a variety of diseases.

[Indexed for MEDLINE]

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