Abstract
Over the past few years, there has been an explosion of data in the scientific literature regarding the various components of the IGF axis. IGFBPs and related molecules are now believed to be critical elements in numerous cellular processes and key factors in several disease states related to abnormal tissue and somatic growth. Recently, the BP-Prs were included in this complex system, and their importance is being unraveled. The upcoming years will undoubtedly bring even more information on the molecular biology of these key cellular regulators. These discoveries are likely to lead to better understanding of growth and cellular regulation and to development of novel therapeutic approaches to a variety of diseases.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Biological Evolution
-
Carrier Proteins / physiology
-
Cathepsins / physiology
-
Endopeptidases / physiology
-
Humans
-
Insulin-Like Growth Factor Binding Protein 1 / physiology
-
Insulin-Like Growth Factor Binding Protein 2 / physiology
-
Insulin-Like Growth Factor Binding Protein 3 / physiology
-
Insulin-Like Growth Factor Binding Protein 4 / physiology
-
Insulin-Like Growth Factor Binding Protein 5 / physiology
-
Insulin-Like Growth Factor Binding Protein 6 / physiology
-
Insulin-Like Growth Factor Binding Proteins / physiology*
-
Metalloendopeptidases / physiology
-
Somatomedins / physiology*
Substances
-
Carrier Proteins
-
Insulin-Like Growth Factor Binding Protein 1
-
Insulin-Like Growth Factor Binding Protein 2
-
Insulin-Like Growth Factor Binding Protein 3
-
Insulin-Like Growth Factor Binding Protein 4
-
Insulin-Like Growth Factor Binding Protein 5
-
Insulin-Like Growth Factor Binding Protein 6
-
Insulin-Like Growth Factor Binding Proteins
-
Somatomedins
-
insulin-like growth factor binding protein-related protein 1
-
Cathepsins
-
Endopeptidases
-
Metalloendopeptidases
-
insulin-like growth factor binding protein-3 protease