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J Antimicrob Chemother. 1996 Aug;38(2):183-91.

Characterization of an inhibitor-resistant enzyme IRT-2 derived from TEM-2 beta-lactamase produced by Proteus mirabilis strains.

Author information

1
Laboratoire de Bactériologie, Faculté de Médecine, Université d'Auvergne, Clermont-Ferrand, France.

Abstract

Ten clinical isolates of Proteus mirabilis were found to produce an inhibitor-resistant TEM beta-lactamase (IRT) in association with a TEM-1 enzyme. The IRT enzyme was derived from TEM-2. The blaIRT gene differs from blaTEM-2 gene by one point mutation which leads to the amino-acid substitution Arg-->Ser at position 244, as observed for the original IRT-2 enzyme derived from TEM-1 reported in Escherichia coli. This is the first report of an IRT beta-lactamase derived from TEM-2.

PMID:
8877532
DOI:
10.1093/jac/38.2.183
[Indexed for MEDLINE]

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