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Immunol Lett. 1996 Aug;52(1):23-30.

Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes.

Author information

1
Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA.

Abstract

HIV-1 infection stimulates a strong CTL response that coincides with resolution of viremia in acute infection and declines with development of opportunistic infections. Recognition of HIV gp160 by PBMC-derived T cell lines from 20 HIV-infected subjects is dominated by the response to a small number of peptide epitopes. Overlapping CTL epitopes restricted by multiple MHC Class I elements were identified in 3 relatively conserved regions of gp160 (amino acids 49-68, 591-600 and 844-863). CTL from five of 20 subjects recognized three overlapping immunodominant epitopes in the 49-68 a.a. region restricted by A24, B38, and B55. CTL from four subjects recognized at least three distinct epitopes in a.a 591-600 in the context of A24, B8, B14, and B27. CTL from seven subjects recognized epitopes within a.a. 844-863 restricted by A30, B7, B8 and B35.

PMID:
8877415
DOI:
10.1016/0165-2478(96)02574-6
[Indexed for MEDLINE]

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