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Eur J Pediatr. 1996 Sep;155(9):775-9.

Severe tick-borne encephalitis following passive immunization.

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Universit├Ątskinderklinik, Z├╝rich, Switzerland.


We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing numbers of B-cells after initial T-cell pleocytosis. Focal central lesions were evident on MRI.


The severity of the presented case questions the benefit of passive immunization and rather justifies consideration of vaccine recommendation to residents and travellers to areas endemic for tick-borne encephalitis virus.

[Indexed for MEDLINE]

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