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Int J Biomed Comput. 1996 Jun;41(3):153-65.

A method for the estimation of the hemoglobin distribution in gastroscopic images.

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GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Medizinische Informatik und Systemforschung Neuherberg, Oberschleissheim, Germany.


The assessment of blood flow in the gastrointestinal mucosa could be a useful indicator for the diagnosis and treatment of several diseases, such as ulcers, gastritis, colitis or early cancer. The quantity of blood flow is roughly estimated by computing the spatial hemoglobin distribution in the mucosa. The method presented here enables a practical realization by calculating approximately the hemoglobin concentration based on a spectrophotometric analysis of endoscopic true-color images, which are recorded during routine examinations. A system model based on the reflectance spectroscopic law of Kubelka-Munk is derived, which enables an estimation of the hemoglobin concentration by means of the color values of the images. Additionally, a transformation of the color values is developed, in order to improve the luminance independence. Applying this transformation and estimating the hemoglobin concentration for each pixel of interest, the hemoglobin distribution can be computed. The results obtained are mostly independent of luminance. An initial validation of the method is made by a quantitative estimation of the reproducibility.

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