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Trends Biochem Sci. 1996 May;21(5):186-90.

Structural and mechanistic relationships between nucleic acid polymerases.

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Department of Biochemistry, University of Texas Health Sciences Center, San Antonio, TX, USA.


A superfamily of nucleic acid polymerases that includes the pol I and pol alpha classes of DNA-directed DNA polymerases, mitochondrial and phage DNA-directed RNA polymerases, and most RNA-directed polymerases may be defined on the basis of the occurrence of conserved sequence motifs and tertiary structure similarities between HIV-1 reverse transcriptase, DNA polymerase I and T7 RNA polymerase. Although sequence or structural similarities do not yet justify inclusion of the multi-subunit DNA-directed RNA polymerases in this superfamily, mechanistic similarities suggest a deep relationship between these and the simpler T7-like RNA polymerases.

[Indexed for MEDLINE]

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