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Trends Biochem Sci. 1996 Sep;21(9):351-5.

The RNA polymerase II general elongation factors.

Author information

1
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted action of a set of general transcription factors that control the activity of polymerase during both the initiation and elongation stages of transcription. To date, five general elongation factors [P-TEFb, SII, TFIIF, Elongin (SIII) and ELL] have been defined biochemically. Here, we discuss these transcription factors and their roles in controlling the activity of the RNA polymerase II elongation complex.

PMID:
8870500
PMCID:
PMC3374595
[Indexed for MEDLINE]
Free PMC Article

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