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Trends Biochem Sci. 1996 Sep;21(9):327-35.

The role of general initiation factors in transcription by RNA polymerase II.

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Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021, USA.


Transcription initiation on protein-encoding genes represents a major control point for gene expression in eukaryotes, and is mediated by RNA polymerase II and a surprisingly complex array of general initiation factors (TFIIA, -B, -D, -E, -F and -H) that are highly conserved from yeast to man. Elucidation of structural and functional features of these factors on model promoters has revealed insights into biochemical mechanisms and provides a basis for understanding their regulation on diverse promoters by gene- and cell-specific activators.

[Indexed for MEDLINE]

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