Format

Send to

Choose Destination
Trends Genet. 1996 Mar;12(3):102-9.

Regulated synthesis, transport and assembly of the Drosophila germ plasm.

Author information

1
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. rongo@wi.mit.edu

Abstract

Germ cells are set aside during early development and, in many organisms (including Drosophila melanogaster, Caenorhabditis elegans and Xenopus laevis), they form in a unique cytoplasm, termed the germ plasm. The germ plasm is synthesized during oogenesis, and the initial polarization of the oocyte is likely to determine where the germ plasm will form within the egg cell. Although we do not know how the fate of germ cells is specified in any organism, recent genetic analysis in Drosophila has identified the TGF-alpha homolog gurken as the signal involved in the initial polarization of the oocyte. These results imply that the limiting steps in the assembly of the germ plasm are localization of the OSK RNA and regulated synthesis of the OSK protein, encoded by oskar, which are components of the germ plasm.

PMID:
8868348
DOI:
10.1016/0168-9525(96)81421-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center