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Dermatology. 1996;192(4):334-6.

Efficacy of oral low-dose tretinoin (all-trans-retinoic acid) in lichen planus.

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  • 1Z├╝rich, Pharmaceutical Research, Basel, Switzerland.

Abstract

BACKGROUND:

Retinoids were shown to be effective in the treatment of both oral and cutaneous forms of lichen planus.

OBJECTIVE:

Confirm the beneficial effect of low doses of oral tretinoin in lichen planus.

METHODS:

Eighteen patients with lichen planus were treated in an open study for up to 19 months. Efficacy and safety data were recorded.

RESULTS:

Complete remission was observed in 13 (72%) and marked improvement in 4 (22%) out of 18 patients. Six patients showed moderate and 12 had no side effects.

CONCLUSION:

Tretinoin is a valuable drug when given at low doses to patients with lichen planus who failed to respond to other therapies.

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PMID:
8864368
[PubMed - indexed for MEDLINE]
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