Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways

Cytokine Growth Factor Rev. 1996 Jun;7(1):81-91. doi: 10.1016/1359-6101(96)00007-x.

Abstract

In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1) was identified by coupling expression cloning with an embryonic stem cell-based model of cardiogenesis. CT-1 is a new member of the IL-6 family of cytokines that induce their biological effects through the shared signaling subunit, gp 130. The expression pattern of CT-1 and its range of activities in the hematopoietic, neuronal, and developmental assays suggest that CT-1 may play an important role in other organ systems, in addition to its actions in cardiac development and hypertrophy.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD / physiology*
  • Cardiomegaly / pathology
  • Cardiomegaly / physiopathology
  • Cells, Cultured
  • Cytokine Receptor gp130
  • Cytokines / genetics
  • Cytokines / physiology*
  • Growth Inhibitors*
  • Humans
  • Interleukin-6*
  • Leukemia Inhibitory Factor
  • Leukemia Inhibitory Factor Receptor alpha Subunit
  • Lymphokines / physiology*
  • Membrane Glycoproteins / physiology*
  • Molecular Sequence Data
  • Receptors, Cytokine / physiology*
  • Receptors, OSM-LIF
  • Signal Transduction / physiology*

Substances

  • Antigens, CD
  • Cytokines
  • Growth Inhibitors
  • IL6ST protein, human
  • Interleukin-6
  • LIF protein, human
  • LIFR protein, human
  • Leukemia Inhibitory Factor
  • Leukemia Inhibitory Factor Receptor alpha Subunit
  • Lymphokines
  • Membrane Glycoproteins
  • Receptors, Cytokine
  • Receptors, OSM-LIF
  • Cytokine Receptor gp130
  • cardiotrophin 1