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Cytokine Growth Factor Rev. 1996 Jun;7(1):81-91.

Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways.

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Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080-4990, USA.


In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1) was identified by coupling expression cloning with an embryonic stem cell-based model of cardiogenesis. CT-1 is a new member of the IL-6 family of cytokines that induce their biological effects through the shared signaling subunit, gp 130. The expression pattern of CT-1 and its range of activities in the hematopoietic, neuronal, and developmental assays suggest that CT-1 may play an important role in other organ systems, in addition to its actions in cardiac development and hypertrophy.

[Indexed for MEDLINE]

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