Abstract
In a search for novel factors that induce cardiac myocyte hypertrophy, cardiotrophin-1 (CT-1) was identified by coupling expression cloning with an embryonic stem cell-based model of cardiogenesis. CT-1 is a new member of the IL-6 family of cytokines that induce their biological effects through the shared signaling subunit, gp 130. The expression pattern of CT-1 and its range of activities in the hematopoietic, neuronal, and developmental assays suggest that CT-1 may play an important role in other organ systems, in addition to its actions in cardiac development and hypertrophy.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, CD / physiology*
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Cardiomegaly / pathology
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Cardiomegaly / physiopathology
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Cells, Cultured
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Cytokine Receptor gp130
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Cytokines / genetics
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Cytokines / physiology*
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Growth Inhibitors*
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Humans
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Interleukin-6*
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Leukemia Inhibitory Factor
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Leukemia Inhibitory Factor Receptor alpha Subunit
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Lymphokines / physiology*
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Membrane Glycoproteins / physiology*
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Molecular Sequence Data
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Receptors, Cytokine / physiology*
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Receptors, OSM-LIF
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Signal Transduction / physiology*
Substances
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Antigens, CD
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Cytokines
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Growth Inhibitors
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IL6ST protein, human
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Interleukin-6
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LIF protein, human
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LIFR protein, human
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Leukemia Inhibitory Factor
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Leukemia Inhibitory Factor Receptor alpha Subunit
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Lymphokines
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Membrane Glycoproteins
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Receptors, Cytokine
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Receptors, OSM-LIF
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Cytokine Receptor gp130
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cardiotrophin 1