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Brain Res. 1996 Apr 1;714(1-2):226-30.

Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat.

Author information

1
School of Agricultural Sciences, Nagoya University, Nagoya, Japan.

Abstract

Dilute-opisthotonus (dop) is a spontaneous ataxic mutation in the rat, regulated by an autosomal recessive gene. Immunohistochemical staining with anti-inositol 1,4,5-trisphosphate receptor antibody and electron microscopic examinations revealed that the endoplasmic reticulum in dendritic spines of Purkinje cell was missing in the ataxic rat. This could impair the intracellular signal transduction in the parallel fiber-Purkinje cell synapse, and be a cause of the severe ataxic movement.

PMID:
8861629
DOI:
10.1016/0006-8993(95)01560-4
[Indexed for MEDLINE]

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