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Arch Ophthalmol. 1996 Oct;114(10):1181-2.

Uveitis associated with topical beta-blockers.

Author information

1
Jaeb Center for Health Research, Tampa, USA. beck@jaeb.com

Abstract

OBJECTIVE:

To assess the incidence of uveitis associated with topical beta-blockers.

DESIGN:

Retrospective cohort study.

SETTING:

A computerized database of a health maintenance organization was used to identify patients who were prescribed metipranolol or other beta-blockers.

PATIENTS:

Two groups: 1928 patients using 0.3% metipranolol and 3903 patients using other beta-blockers.

MAIN OUTCOME MEASURE:

Cases of uveitis were identified by noting a prescription of a topical corticosteroid and then conducting a chart review.

RESULTS:

No cases of uveitis were identified among the 5831 patients. The upper limits of the 95% confidence intervals for the incidence of uveitis in cohorts of this size are 1.87 cases per 1000 person-years of exposure for metipranolol and 1.38 for other beta-blockers.

CONCLUSION:

Drug-induced uveitis from metipranolol or other beta-blocker administration is a rare event, even if a causal relationship exists.

[Indexed for MEDLINE]

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