Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Perinatol. 1996 Apr;20(2):140-6.

The effect of cocaine on myometrial contractile activity: basic mechanisms.

Author information

1
Department Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center-Houston 77030, USA.

Abstract

Several clinical studies have reported an association between cocaine use in pregnancy and preterm labor. The mechanism by which cocaine exerts this effect is unclear. Although cocaine stimulates isolated myometrial contractile activity, results using whole animal models are conflicting. Although cocaine inhibits uterine neuronal and extraneuronal uptake of catecholamines and increases circulating levels of catecholamines in experimental animals, it is unlikely that facilitation of the alpha-adrenergic pathway is the sole mechanism of cocaine's action. Further investigation of possible indirect mechanisms of action including altered prostaglandin production, inhibition of beta-adrenergic response, and direct effects on intracellular calcium mobilization may lead to enhanced understanding of the clinical ramifications of cocaine use during pregnancy.

PMID:
8857699
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center