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Nature. 1996 Oct 17;383(6601):598-603.

Structure of a replication-terminator protein complexed with DNA.

Author information

1
Department of Genetics, The Graduate University for Advanced Studies, and National Institute of Genetics, Shizuoka, Japan.

Abstract

The crystal structure of the Escherichia coli replication-terminator protein (Tus) bound to terminus-site (Ter) DNA has been determined at 2.7 A resolution. The Tus protein folds into a previously undescribed architecture divided into two domains by a central basic cleft. This cleft accommodates locally deformed B-form Ter DNA and makes extensive contacts with the major groove, mainly through two interdomain beta-strands. The unusual structural features of this complex may explain how the replication fork is halted in only one direction.

PMID:
8857533
DOI:
10.1038/383598a0
[Indexed for MEDLINE]

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