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Intensive Care Med. 1996 Jan;22(1):65-70.

Circulatory and diuretic effects of dopexamine infusion in low-birth-weight infants with respiratory failure.

Author information

1
Intensive Care Unit, Paediatric Hospital, University School of Medicine, Lodz, Poland.

Abstract

OBJECTIVE:

To investigate the effects of infusion of dopexamine hydrochloride, a new synthetic catecholamine, on cardiopulmonary status and urine output in neonates with respiratory and circulatory failure.

DESIGN:

Prospective clinical study with each patient serving as his own control.

SETTING:

Intensive care unit (14 beds) in a 300-bed paediatric teaching hospital.

PATIENTS:

Seventeen neonates with low birth weight (LBW) requiring mechanical ventilation in the first 4 days of life, who initially had two of the following symptoms: hypotension, oliguria, metabolic acidosis with base deficit >10 and failure to respond to volume loading.

INTERVENTIONS:

Cardiopulmonary variables, diuresis and acid-base status were measured before and after volume loading, in patients who did not improve infusion of dopexamine was started at a dose of 2 microg kg-1 min-1 which was titrated to achieve blood pressure, urine output, and base deficit in normal range. Observations were continued for a period of 5 h.

MEASUREMENTS AND RESULTS:

Systolic blood pressure increased significantly after 3 h. of dopexamine infusion and remained elevated up to the end of the study period. Diastolic and mean blood pressure increased slightly (NS). Diuresis increased significantly from the 4th h of dopexamine infusion. Arterial blood pH increased significantly from baseline at 5 h after the start of dopexamine administration. There was also a significant improvement in the PtcO2/PaO2 index.

CONCLUSION:

In neonates with respiratory and circulatory failure, dopexamine increases blood pressure and improves arterial pH and urine output.

PMID:
8857441
DOI:
10.1007/bf01728334
[Indexed for MEDLINE]

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