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Exp Clin Immunogenet. 1996;13(1):12-9.

Met-11 of HLA class II DP alpha 1 first domain associated with onchocerciasis.

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Department of Molecular Biology, Institute for Tropical Medicine, Berlin, Germany.


Human infection with the pathogenic tissue nematode Onchocerca volvulus may result in a spectrum of clinical manifestations or in a putatively immune condition. A methionine at amino acid position 11 of the HLA class II DP alpha 1 chain correlates with the occurring disease after infection (relative risk 3.3). The alternative alanine at position 11 is, conversely, associated with protection from disease ("relative protection' 3.5). DPA1*0301 is associated with the localized form of disease after O. volvulus infection.

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