Abstract
Human infection with the pathogenic tissue nematode Onchocerca volvulus may result in a spectrum of clinical manifestations or in a putatively immune condition. A methionine at amino acid position 11 of the HLA class II DP alpha 1 chain correlates with the occurring disease after infection (relative risk 3.3). The alternative alanine at position 11 is, conversely, associated with protection from disease ("relative protection' 3.5). DPA1*0301 is associated with the localized form of disease after O. volvulus infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Disease Susceptibility
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Epitopes / genetics
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Epitopes / immunology
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Genetic Linkage / genetics*
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HLA-DP Antigens / genetics*
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HLA-DP Antigens / immunology
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HLA-DP alpha-Chains
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HLA-DP beta-Chains
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Haplotypes / genetics
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Humans
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Methionine / analysis*
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Molecular Sequence Data
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Onchocerca volvulus / pathogenicity
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Onchocerciasis / genetics*
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Onchocerciasis / physiopathology
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Risk Factors
Substances
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Epitopes
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HLA-DP Antigens
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HLA-DP alpha-Chains
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HLA-DP beta-Chains
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HLA-DPA1 antigen
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HLA-DPB1 antigen
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Methionine