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Antimicrob Agents Chemother. 1996 Apr;40(4):1024-6.

Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic localities.

Author information

1
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

Two genes (rpsL and rrs) with mutations associated with streptomycin resistance in Mycobacterium tuberculosis were characterized in 78 streptomycin-resistant and 61 streptomycin-susceptible isolates recovered from patients living in the United States, South America, Europe, Africa, and Asia. Fifty-four percent of the 78 resistant organisms had missense mutations in codon 43 of rpsL resulting in a K-43-->R substitution. Mutations in codon 88 of rpsL were also identified in four Asian isolates.

PMID:
8849220
PMCID:
PMC163252
[Indexed for MEDLINE]
Free PMC Article

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